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Article

Nuclear Excluded Autism-Associated Phosphatase and Tensin Homolog Mutations Dysregulate Neuronal Growth.

Biological psychiatry - 15 Aug 2018

Fricano-Kugler Catherine J, Getz Stephanie A, Williams Michael R, Zurawel Ashley A, DeSpenza Tyrone, Frazel Paul W, Li Meijie, O'Malley Alistair J, Moen Erika L, Luikart Bryan W

Abstract excerpt

BACKGROUND: Phosphatase and tensin homolog (PTEN) negatively regulates downstream protein kinase B signaling, resulting in decreased cellular growth and proliferation. PTEN is mutated in a subset of children with autism spectrum disorder (ASD); however, the mechanism by which specific point mutations alter PTEN function is largely unknown. Here, we assessed how ASD-associated single-nucleotide variations in PTEN...

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Identifiers

PMID: 29373119
DOI: 10.1016/j.biopsych.2017.11.025
PMCID: PMC5984669

Genes

PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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