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Article

Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility.

The Journal of biological chemistry - 15 Jun 2018

Igarashi Atsushi, Itoh Kie, Yamada Tatsuya, Adachi Yoshihiro, Kato Takashi, Murata Daisuke, Sesaki Hiromi, Iijima Miho

Abstract excerpt

Defects in phosphatase and tensin homolog (PTEN) are associated with neurological disorders and tumors. PTEN functions at two primary intracellular locations: the plasma membrane and the nucleus. At the membrane, PTEN functions as a phosphatidylinositol (3,4,5)-trisphosphate phosphatase and suppresses PI 3-kinase signaling that drives cell growth and tumorigenesis. However, the in vivo function of nuclear PTEN is...

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Source

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Identifiers

PMID: 29735527
DOI: 10.1074/jbc.RA118.002356
PMCID: PMC6005449

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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