Article
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Science (New York, N.Y.) - 26 Jul 2013
Hopkins Benjamin D, Fine Barry, Steinbach Nicole, Dendy Meaghan, Rapp Zachary, Shaw Jacquelyn, Pappas Kyrie, Yu Jennifer S, Hodakoski Cindy, Mense Sarah, Klein Joshua, Pegno Sarah, Sulis Maria-Luisa, Goldstein Hannah, Amendolara Benjamin, Lei Liang, Maurer Matthew, Bruce Jeffrey, Canoll Peter, Hibshoosh Hanina, Parsons Ramon
Abstract excerpt
Phosphatase and tensin homolog on chromosome ten (PTEN) is a tumor suppressor and an antagonist of the phosphoinositide-3 kinase (PI3K) pathway. We identified a 576-amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base pairs up...
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