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Article

Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention.

The Journal of clinical endocrinology and metabolism - 1 May 2007

Stefan Norbert, Thamer Claus, Staiger Harald, Machicao Fausto, Machann Jürgen, Schick Fritz, Venter Christian, Niess Andreas, Laakso Markku, Fritsche Andreas, Häring Hans-Ulrich

Abstract excerpt

CONTEXT: Mitochondrial function is associated with aerobic physical fitness and insulin sensitivity and may play an important role in the pathophysiology of type 2 diabetes. Peroxisome proliferator-activated receptor (PPAR)-delta (gene PPARD) and PPARgamma coactivator 1alpha (gene PPARGC1A) are determinants of mitochondrial function in animals and in vitro. OBJECTIVE: The objective of this study was to establish...

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Source

Identifiers

PMID: 17327385
DOI: 10.1210/jc.2006-1785

Genes

PPARD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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