Article
Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake.
Diabetes - 1 Dec 2005
Vänttinen Markku, Nuutila Pirjo, Kuulasmaa Teemu, Pihlajamäki Jussi, Hällsten Kirsti, Virtanen Kirsi A, Lautamäki Riikka, Peltoniemi Pauliina, Takala Teemu, Viljanen Antti P M, Knuuti Juhani, Laakso Markku
Abstract excerpt
The peroxisome proliferator-activated receptors (PPARs) belong to a superfamily of nuclear receptors. It includes PPAR-delta, a key regulator of fatty acid oxidation and energy uncoupling, universally expressed in different tissues. The PPAR-delta gene (PPARD) maps to 6p21.2-p21.1 and has 11 exons and spans 35 kbp. We investigated the effects of single nucleotide polymorphisms (SNPs) of PPARD on whole-body,...
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