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Article

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance.

Diabetologia - 1 May 2014

Kristensen Jonas M, Skov Vibe, Petersson Stine J, Ørtenblad Niels, Wojtaszewski Jørgen F P, Beck-Nielsen Henning, Højlund Kurt

Abstract excerpt

AIMS/HYPOTHESIS: Insulin resistance in obesity and type 2 diabetes is related to abnormalities in mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. We tested the hypothesis that mitochondrial oxidative metabolism is impaired in muscle of patients with inherited insulin resistance and defective insulin signalling. METHODS: Skeletal muscle biopsies obtained from carriers (n = 6) of a mutation in...

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Source

Identifiers

PMID: 24510228
DOI: 10.1007/s00125-014-3187-y

Genes

PGC
INSR
SDHA
UQCRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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