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Article

Effect of Single-Residue Mutations on CTCF Binding to DNA: Insights from Molecular Dynamics Simulations.

International journal of molecular sciences - 29 Mar 2023

Mao Albert, Chen Carrie, Portillo-Ledesma Stephanie, Schlick Tamar

Abstract excerpt

In humans and other eukaryotes, DNA is condensed into chromatin fibers that are further wound into chromosomes. This organization allows regulatory elements in the genome, often distant from each other in the linear DNA, to interact and facilitate gene expression through regions known as topologically associating domains (TADs). CCCTC-binding factor (CTCF) is one of the major components of TAD formation and is...

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PMID: 37047368
DOI: 10.3390/ijms24076395
PMCID: PMC10094706

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