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Article

Genetic variations of CYP3A4 on the metabolism of itraconazole in vitro.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Nov 2023

Xie Sai-Li, Zhu Xiayan, Gao Nanyong, Lin Qianmeng, Chen Chaojie, Yang Yun-Jun, Cai Jian-Ping, Hu Guo-Xin, Xu Ren-Ai

Abstract excerpt

Itraconazole is a triazole anti-infective drug that has been proven to prevent and treat a variety of fungal and viral infections and has been considered to be a potential therapeutic remedy for COVID-19 treatment. In this study, we aimed to completely evaluate the impacts of Cytochrome P450 3A4 (CYP3A4) variant proteins and drug interactions on the metabolism of itraconazole in recombinant insect microsomes, and...

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PMID: 37863381
DOI: 10.1016/j.fct.2023.114101

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