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Article

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

6 Sept 2018

Abstract excerpt

Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest and undergo repair processes. Perturbations in genomic stability can lead to tumor development and suggest that...

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PMID: 30190546
DOI: 10.1038/s41388-018-0464-0

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