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Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders

2024-09-23

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic adenocarcinoma (PDAC) is a rapidly progressing cancer that responds poorly to immunotherapies. Intratumoral tertiary lymphoid structures (TLS) have been associated with rare long-term PDAC survivors, but the role of TLS in PDAC and their spatial relationships within the context of the broader tumor microenvironment remain unknown. We generated a spatial multi-omics atlas encompassing...

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Literature Corpus work
97393c82-b4dd-51e4-80c7-66793f687ac0
DOI
10.1101/2024.09.22.613714
Open publication

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Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic respondersDOI 10.1101/2024.09.22.613714
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