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Article

Topography of epithelial-mesenchymal plasticity.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2018

Font-Clos Francesc, Zapperi Stefano, La Porta Caterina A M

Abstract excerpt

The transition between epithelial and mesenchymal states has fundamental importance for embryonic development, stem cell reprogramming, and cancer progression. Here, we construct a topographic map underlying epithelial-mesenchymal transitions using a combination of numerical simulations of a Boolean network model and the analysis of bulk and single-cell gene expression data. The map reveals a multitude of...

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Identifiers

PMID: 29784817
DOI: 10.1073/pnas.1722609115
PMCID: PMC6003369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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