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Article

A hybrid model of intercellular tension and cell-matrix mechanical interactions in a multicellular geometry.

Biomechanics and modeling in mechanobiology - 1 Dec 2020

Scott Lewis E, Griggs Lauren A, Narayanan Vani, Conway Daniel E, Lemmon Christopher A, Weinberg Seth H

Abstract excerpt

Epithelial cells form continuous sheets of cells that exist in tensional homeostasis. Homeostasis is maintained through cell-to-cell junctions that distribute tension and balance forces between cells and their underlying matrix. Disruption of tensional homeostasis can lead to epithelial-mesenchymal transition (EMT), a transdifferentiation process in which epithelial cells adopt a mesenchymal phenotype, losing...

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Identifiers

PMID: 32193709
DOI: 10.1007/s10237-020-01321-8
PMCID: PMC7502553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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