Article
Genomic comparison between cerebrospinal fluid and primary tumor revealed the genetic events associated with brain metastasis in lung adenocarcinoma.
Cell death & disease - 12 Oct 2021
Deng Zhiyong, Cui Liang, Li Pansong, Ren Nianjun, Zhong Zhe, Tang Zhi, Wang Lei, Gong Jianwu, Cheng Haofeng, Guan Yanfang, Yi Xin, Xia Xuefeng, Zhou Rongrong, He Zhengwen
Abstract excerpt
Lung adenocarcinoma (LUAD) is most common pathological type of lung cancer. LUAD with brain metastases (BMs) usually have poor prognosis. To identify the potential genetic factors associated with BM, a genomic comparison for BM cerebrospinal fluid (CSF) and primary lung tumor samples obtained from 1082 early- and late-stage LUAD patients was performed. We found that single nucleotide variation (SNV) of EGFR was...
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