Article
Association of Cerebrospinal Fluid Tumor DNA Genotyping With Survival Among Patients With Lung Adenocarcinoma and Central Nervous System Metastases.
JAMA network open - 3 Aug 2020
Li Yang-Si, Zheng Mei-Mei, Jiang Ben-Yuan, Tu Hai-Yan, Yang Jin-Ji, Zhang Xu-Chao, Wu Yi-Long
Abstract excerpt
Importance: Owing to the improvement of systemic therapies for lung cancer, patients live longer, but the incidence of central nervous system (CNS) metastases also increases. Cerebrospinal fluid (CSF) has been proven better than plasma to reveal unique genetic profiling of intracranial metastases. How genetic alterations in CSF are associated with the prognosis of this heterogeneous patient group remains elusive....
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