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Article

Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison.

International journal of molecular sciences - 22 Sept 2021

Parikh Sonia J, Kamat Sumit, Phillips Margaret, Boyson Samuel P, Yarbrough Thomas, Davie Dylan, Zhang Qinghai, Glass Karen C, Shah Manish B

Abstract excerpt

Cytochromes P450 (CYP) are one of the major xenobiotic metabolizing enzymes with increasing importance in pharmacogenetics. The CYP2C9 enzyme is responsible for the metabolism of a wide range of clinical drugs. More than sixty genetic variations have been identified in CYP2C9 with many demonstrating reduced activity compared to the wild-type (WT) enzyme. The CYP2C9*8 allele is predominantly found in persons of...

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Identifiers

PMID: 34638547
DOI: 10.3390/ijms221910206
PMCID: PMC8508694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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