Article
Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Dec 2020
Derayea Sayed M, Tsujino Hirofumi, Oyama Yukiko, Ishikawa Yoshinobu, Yamashita Taku, Uno Tadayuki
Abstract excerpt
Although CYP2C19 is minor human liver enzyme, it is responsible for the metabolism of many clinically important drugs. In this work, CYP2C19 wild type and its SNP mutants (R132Q and W120R) were prepared using over-expression system in E. coli, purified by column chromatography and their biological activities were compared. The enzyme activity toward certain drugs (amitriptyline, imipramine, lansoprazole and...
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