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Article

Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9*30.

PloS one - 1 Jan 2018

Louet Maxime, Labbé Céline M, Fagnen Charline, Aono Cassiano M, Homem-de-Mello Paula, Villoutreix Bruno O, Miteva Maria A

Abstract excerpt

Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs. The allelic variant CYP2C9*30 (A477T) is associated to diminished response to the antihypertensive effects of the prodrug losartan and affected metabolism of other drugs. Here, we investigated molecular mechanisms involved in the functional consequences of this amino-acid substitution. Molecular dynamics (MD) simulations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29746595
DOI: 10.1371/journal.pone.0197249
PMCID: PMC5944999

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