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Article

Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9.

Biochemistry - 17 Oct 2017

Maekawa Keiko, Adachi Motoyasu, Matsuzawa Yumiko, Zhang Qinghai, Kuroki Ryota, Saito Yoshiro, Shah Manish B

Abstract excerpt

Single-nucleotide polymorphisms in drug-metabolizing cytochrome P450 (CYP) enzymes are important contributors to interindividual differences in drug metabolism leading to adverse drug reactions. Despite their extensive characterization and importance in pharmacogenetics of clinical drugs, the structural basis of CYP polymorphisms has remained scant. Here we report the crystal structures of human CYP2C9 and its...

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Identifiers

PMID: 28972767
DOI: 10.1021/acs.biochem.7b00795
PMCID: PMC5761073

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