Article
Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism.
Molecular pharmacology - 1 Nov 2020
Parikh Sonia J, Evans Chiara M, Obi Juliet O, Zhang Qinghai, Maekawa Keiko, Glass Karen C, Shah Manish B
Abstract excerpt
The human CYP2C9 plays a crucial role in the metabolic clearance of a wide range of clinical therapeutics. The *2 allele is a prevalent genetic variation in CYP2C9 that is found in various populations. A marked reduction of catalytic activity toward many important drug substrates has been demonstrated by CYP2C9*2, which represents an amino acid variation at position 144 from arginine to cysteine. The crystal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.