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Article

Antiproliferative effects of metformin in cellular models of pheochromocytoma.

Molecular and cellular endocrinology - 1 Jan 2022

Meireles Cinthia Gabriel, Lourenço de Lima Caroline, Martins de Paula Oliveira Marcela, Abe da Rocha Miranda Rafael, Romano Lisa, Yo-Stella Brashaw Teisha, Neves da Silva Guerra Eliete, de Assis Rocha Neves Francisco, Chapple J Paul, Simeoni Luiz Alberto, Lofrano-Porto Adriana

Abstract excerpt

Pheochromocytomas (PCCs) are rare neuroendocrine tumors derived from adrenal medulla chromaffin cells. Malignancy and recurrence are rare but demand effective treatment. Metformin exerts antiproliferative effects in several cancer cell lines. We thus evaluated the effects of metformin on cell viability and proliferation, cellular respiration and AMPK-AKT-mTOR-HIFA proliferation pathway on a rat PCC cell line...

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Identifiers

PMID: 34637881
DOI: 10.1016/j.mce.2021.111484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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