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Article

HIF Signaling Pathway in Pheochromocytoma and Other Neuroendocrine Tumors

14 Jun 2014

Abstract excerpt

Hypoxia-inducible factors (HIFs) are transcription factors controlling energy, iron metabolism, erythropoiesis, and development. Dysregulation of these proteins contributes to tumorigenesis and cancer progression. Recent findings revealed the important role of HIFs in the pathogenesis of neuroendocrine tumors, especially pheochromocytoma (PHEO) and paraganglioma (PGL). PHEOs and PGLs are catecholamine-producing...

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PMID: 24908231
DOI: 10.33549/physiolres.932789

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