Article
Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient-Derived Xenografts.
Molecular cancer therapeutics - 1 Sept 2017
Mohamed Suhaimi Nur-Afidah, Phyo Wai Min, Yap Hao Yun, Choy Sharon Heng Yee, Wei Xiaona, Choudhury Yukti, Tan Wai Jin, Tan Luke Anthony Peng Yee, Foo Roger Sik Yin, Tan Suzanne Hui San, Tiang Zenia, Wong Chin Fong, Koh Poh Koon, Tan Min-Han
Abstract excerpt
There is increasing preclinical evidence suggesting that metformin, an antidiabetic drug, has anticancer properties against various malignancies, including colorectal cancer. However, the majority of evidence, which was derived from cancer cell lines and xenografts, was likely to overestimate the benefit of metformin because these models are inadequate and require supraphysiologic levels of metformin. Here, we...
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