Article
Genotype-specific differences in the tumor metabolite profile of pheochromocytoma and paraganglioma using untargeted and targeted metabolomics.
The Journal of clinical endocrinology and metabolism - 1 Feb 2015
Rao J U, Engelke U F H, Sweep F C G J, Pacak K, Kusters B, Goudswaard A G, Hermus A R M M, Mensenkamp A R, Eisenhofer G, Qin N, Richter S, Kunst H P M, Timmers H J L M, Wevers R A
Abstract excerpt
CONTEXT AND OBJECTIVE: Pheochromocytomas and paragangliomas (PGLs) are neuroendocrine tumors of sympathetic or parasympathetic paraganglia. Nearly 40% of PGLs are caused by germline mutations. The present study investigated the effect of genetic alterations on metabolic networks in PGLs. DESIGN: Homogenates of 32 sporadic PGLs and 48 PGLs from patients with mutations in SDHB, SDHD, SDHAF-2, VHL, RET, and NF-1...
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