Article

The effect of metformin on human clear cell renal cell carcinoma energy metabolism. Identification of adenine nucleotide translocator as a novel target of metformin

2025-10-07

Abstract excerpt

<title>Abstract</title> <p> Although metformin (MET), the well-known antidiabetic drug, exhibits clear antineoplastic effects and is reported to target mitochondria, several issues are still open in this regard, thus limiting its utilization as an anticancer drug alone or in combination with other molecules. Here a functional investigation was carried out to reveal how MET impacted on mitochondrial functions and...

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Literature Corpus work: 97272a7f-c7fe-57b8-864b-036deb4c5e6d
DOI: 10.21203/rs.3.rs-7582770/v1

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