Article
Phospho-mTOR is not upregulated in metastatic SDHB paragangliomas.
European journal of clinical investigation - 1 Sept 2013
Ghayee Hans K, Giubellino Alessio, Click Arielle, Kapur Payal, Christie Alana, Xie Xian-Jin, Martucci Victoria, Shay Jerry W, Souza Rhonda F, Pacak Karel
Abstract excerpt
BACKGROUND: Pheochromocytomas (PCCs)/paragangliomas (PGLs) are neuroendocrine tumours that may cause arrhythmia and death if untreated. Treatment for patients with metastatic tumours is lacking. As new PCC/PGL susceptibility genes are discovered that are associated with the mTOR pathway, treatment targets focusing on this pathway are being intensively explored. DESIGN: Twenty-one human PCC/PGLs were analysed from...
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