Article
Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.
The Journal of biological chemistry - 15 Sept 2017
Prakasam Gopinath, Singh Rajnish Kumar, Iqbal Mohammad Askandar, Saini Sunil Kumar, Tiku Ashu Bhan, Bamezai Rameshwar N K
Abstract excerpt
Preferential expression of the low-activity (dimeric) M2 isoform of pyruvate kinase (PK) over its constitutively active splice variant M1 isoform is considered critical for aerobic glycolysis in cancer cells. However, our results reported here indicate co-expression of PKM1 and PKM2 and their possible physical interaction in cancer cells. We show that knockdown of either PKM1 or PKM2 differentially affects net PK...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.