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Article

The mTORC1 Complex Is Significantly Overactivated in SDHX-Mutated Paragangliomas.

Neuroendocrinology - 1 Jan 2017

Oudijk Lindsey, Papathomas Thomas, de Krijger Ronald, Korpershoek Esther, Gimenez-Roqueplo Anne-Paule, Favier Judith, Canu Letizia, Mannelli Massimo, Rapa Ida, Currás-Freixes Maria, Robledo Mercedes, Smid Marcel, Papotti Mauro, Volante Marco

Abstract excerpt

AIM: We aimed at exploring the activation pattern of the mTOR pathway in sporadic and hereditary pheochromocytomas (PCCs) and paragangliomas (PGLs). METHODS: A total of 178 PCCs and 44 PGLs, already characterized for the presence of germline mutations in VHL, RET, NF1, MAX, SDHA, SDHB, SDHC, and SDHD as well as somatic mutations in VHL, RET, H-RAS, and MAX, were included in 5 tissue microarrays and tested using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28122379
DOI: 10.1159/000455864

Genes

VHL
MAX
RET
SDHA
SDHB
SDHC
SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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