Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inverted allosteric coupling between activation and inactivation gates in K+ channels.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018

Labro Alain J, Cortes D Marien, Tilegenova Cholpon, Cuello Luis G

Abstract excerpt

The selectivity filter and the activation gate in potassium channels are functionally and structurally coupled. An allosteric coupling underlies C-type inactivation coupled to activation gating in this ion-channel family (i.e., opening of the activation gate triggers the collapse of the channel's selectivity filter). We have identified the second Threonine residue within the TTVGYGD signature sequence of K+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Allosteric Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to HEK293 Cells

Share to Ion Channel Gating

Share to Potassium

Share to Potassium Channels

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 29735651
DOI: 10.1073/pnas.1800559115
PMCID: PMC6003467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inverted allosteric coupling between activation and inactivation gates in K+ channels.PMID 29735651Read ↗

A different mechanism of C-type inactivation in the Kv-like KcsA mutant E71VSemantic proximity Read ↗

Hysteresis of KcsA potassium channel's activation- deactivation gating is caused by structural changes at the channel's selectivity filter.Semantic proximity Read ↗

A glimpse into the C-type-inactivated state for a Potassium Channel.Semantic proximity Read ↗

Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state.Semantic proximity Read ↗

Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Semantic proximity Read ↗

Closed state-coupled C-type inactivation in BK channels.Semantic proximity Read ↗

Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling.Semantic proximity Read ↗

Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.Semantic proximity Read ↗

K⁺ channel gating: C-type inactivation is enhanced by calcium or lanthanum outside.Semantic proximity Read ↗

Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels.Semantic proximity Read ↗

CaV3.1 channel pore pseudo-symmetry revealed by selectivity filter mutations in its domains I/II.Semantic proximity Read ↗

Transmembrane allosteric coupling of the gates in a potassium channel.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.