Article
Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
BMC medicine - 3 Sept 2020
Seyed Khoei Nazlisadat, Jenab Mazda, Murphy Neil, Banbury Barbara L, Carreras-Torres Robert, Viallon Vivian, Kühn Tilman, Bueno-de-Mesquita Bas, Aleksandrova Krasimira, Cross Amanda J, Weiderpass Elisabete, Stepien Magdalena, Bulmer Andrew, Tjønneland Anne, Boutron-Ruault Marie-Christine, Severi Gianluca, Carbonnel Franck, Katzke Verena, Boeing Heiner, Bergmann Manuela M, Trichopoulou Antonia, Karakatsani Anna, Martimianaki Georgia, Palli Domenico, Tagliabue Giovanna, Panico Salvatore, Tumino Rosario, Sacerdote Carlotta, Skeie Guri, Merino Susana, Bonet Catalina, Rodríguez-Barranco Miguel, Gil Leire, Chirlaque Maria-Dolores, Ardanaz Eva, Myte Robin, Hultdin Johan, Perez-Cornago Aurora, Aune Dagfinn, Tsilidis Konstantinos K, Albanes Demetrius, Baron John A, Berndt Sonja I, Bézieau Stéphane, Brenner Hermann, Campbell Peter T, Casey Graham, Chan Andrew T, Chang-Claude Jenny, Chanock Stephen J, Cotterchio Michelle, Gallinger Steven, Gruber Stephen B, Haile Robert W, Hampe Jochen, Hoffmeister Michael, Hopper John L, Hsu Li, Huyghe Jeroen R, Jenkins Mark A, Joshi Amit D, Kampman Ellen, Larsson Susanna C, Le Marchand Loic, Li Christopher I, Li Li, Lindblom Annika, Lindor Noralane M, Martín Vicente, Moreno Victor, Newcomb Polly A, Offit Kenneth, Ogino Shuji, Parfrey Patrick S, Pharoah Paul D P, Rennert Gad, Sakoda Lori C, Schafmayer Clemens, Schmit Stephanie L, Schoen Robert E, Slattery Martha L, Thibodeau Stephen N, Ulrich Cornelia M, van Duijnhoven Franzel J B, Weigl Korbinian, Weinstein Stephanie J, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Zhang Xuehong, Ferrari Pietro, Anton Gabriele, Peters Annette, Peters Ulrike, Gunter Marc J, Wagner Karl-Heinz, Freisling Heinz
Abstract excerpt
BACKGROUND: Bilirubin, a byproduct of hemoglobin breakdown and purported anti-oxidant, is thought to be cancer preventive. We conducted complementary serological and Mendelian randomization (MR) analyses to investigate whether alterations in circulating levels of bilirubin are associated with risk of colorectal cancer (CRC). We decided a priori to perform analyses separately in men and women based on suggestive...