Article
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
PloS one - 1 Jan 2012
Milton Jacqueline N, Sebastiani Paola, Solovieff Nadia, Hartley Stephen W, Bhatnagar Pallav, Arking Dan E, Dworkis Daniel A, Casella James F, Barron-Casella Emily, Bean Christopher J, Hooper W Craig, DeBaun Michael R, Garrett Melanie E, Soldano Karen, Telen Marilyn J, Ashley-Koch Allison, Gladwin Mark T, Baldwin Clinton T, Steinberg Martin H, Klings Elizabeth S
Abstract excerpt
Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia. When hemolysis occurs circulating heme increases, leading to elevated bilirubin levels and an increased incidence of cholelithiasis. We performed the first genome-wide association study (GWAS) of bilirubin levels and cholelithiasis risk...
Topics
- Black or African American
- Anemia, Sickle Cell
- Bilirubin
- Cholelithiasis
- Cohort Studies
- Genome-Wide Association Study
- Genotype
- Glucuronosyltransferase