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Evolutionary patterns of chromosomal instability and mismatch repair deficiency in proximal and distal colorectal cancer

9 Oct 2021

Abstract excerpt

AIM: Colorectal carcinomas (CRCs) progress through heterogeneous pathways. The aim of this study was to analyse whether or not the cytogenetic evolution of CRC is linked to tumour site, level of chromosomal imbalance and metastasis. METHOD: A set of therapy-naïve pT3 CRCs comprising 26 proximal and 49 distal pT3 CRCs was studied by combining immunohistochemistry of mismatch repair (MMR) proteins, microsatellite...

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PMID: 34623739
DOI: 10.1111/codi.15946

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