Article
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.
The American journal of gastroenterology - 1 Nov 2013
Mouradov Dmitri, Domingo Enric, Gibbs Peter, Jorissen Robert N, Li Shan, Soo Pik Ying, Lipton Lara, Desai Jayesh, Danielsen Havard E, Oukrif Dahmane, Novelli Marco, Yau Christopher, Holmes Christopher C, Jones Ian T, McLaughlin Stephen, Molloy Peter, Hawkins Nicholas J, Ward Robyn, Midgely Rachel, Kerr David, Tomlinson Ian P M, Sieber Oliver M
Abstract excerpt
OBJECTIVES: Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. However, a substantial group of "double-negative" (MSI-/CIN-) CRCs exists. The prognosis of these patients is unclear. Furthermore, MSI and CIN...
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