Article
Refining molecular analysis in the pathways of colorectal carcinogenesis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Nov 2005
Rowan Andrew, Halford Sarah, Gaasenbeek Michelle, Kemp Zoe, Sieber Oliver, Volikos Emmanouil, Douglas Eleanor, Fiegler Heike, Carter Nigel, Talbot Ian, Silver Andrew, Tomlinson Ian
Abstract excerpt
BACKGROUND & AIMS: In the stepwise model, specific genetic and epigenetic changes accumulate as colorectal adenomas progress to carcinomas (CRCs). CRCs also acquire global phenotypes, particularly microsatellite instability (MSI) and aneuploidy/polyploidy (chromosomal instability, CIN). Few changes specific to MSI-low or CIN+ cancers have been established. METHODS: We investigated 100 CRCs for: mutations and loss...
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