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Article

Molecular Events in Primary and Metastatic Colorectal Carcinoma: A Review

9 May 2012

Abstract excerpt

Colorectal cancer (CRC) is a heterogeneous disease, developing through a multipathway sequence of events guided by clonal selections. Pathways included in the development of CRC may be broadly categorized into (a) genomic instability, including chromosomal instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP), (b) genomic mutations including suppression of tumour...

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Identifiers

PMID: 22997602
DOI: 10.1155/2012/597497

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