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Article

Molecular evolution of colorectal cancer: from multistep carcinogenesis to the big bang.

Cancer metastasis reviews - 1 Mar 2016

Amaro Adriana, Chiara Silvana, Pfeffer Ulrich

Abstract excerpt

Colorectal cancer is characterized by exquisite genomic instability either in the form of microsatellite instability or chromosomal instability. Microsatellite instability is the result of mutation of mismatch repair genes or their silencing through promoter methylation as a consequence of the CpG island methylator phenotype. The molecular causes of chromosomal instability are less well characterized. Genomic...

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PMID: 26947218
DOI: 10.1007/s10555-016-9606-4

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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