Article
Genetic classification of colorectal cancer based on chromosomal loss and microsatellite instability predicts survival.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2002
Choi Sang-Wook, Lee Kyung Jun, Bae Young-An, Min Ki-Ouk, Kwon Mi-Seon, Kim Kyoung-Mee, Rhyu Mun-Gan
Abstract excerpt
PURPOSE: Colorectal cancers harbor one of two distinct alterations, unilateral chromosomal loss as evidenced by a loss of heterozygosity (LOH) and microsatellite instability (MSI), as represented by the widespread insertion or deletion of simple repeat nucleotides. We investigated the relationships between the clinicopathological features and microsatellite alterations (LOH and MSI) of 168 colorectal cancers....
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