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Article

Genetic regressive trajectories in colorectal cancer: A new hallmark of oligo-metastatic disease?

23 May 2021

Abstract excerpt

Colorectal cancer (CRC) originates as consequence of multiple genetic alterations. Some of the involved genes have been extensively studied (APC, TP53, KRAS, SMAD4, PIK3CA, MMR genes) in highly heterogeneous and poly-metastatic cohorts. However, about 10% of metastatic CRC patients presents with an indolent oligo-metastatic disease differently from other patients with poly-metastatic and aggressive clinical...

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PMID: 34034007
DOI: 10.1016/j.tranon.2021.101131

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