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Article

Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence.

The Journal of clinical investigation - 1 Dec 2021

Greninger Alexander L, Rybkina Ksenia, Lin Michelle J, Drew-Bear Jennifer, Marcink Tara C, Shean Ryan C, Makhsous Negar, Boeckh Michael, Harder Olivia, Bovier Francesca, Burstein Shana R, Niewiesk Stefan, Rima Bert K, Porotto Matteo, Moscona Anne

Abstract excerpt

The capacity of respiratory viruses to undergo evolution within the respiratory tract raises the possibility of evolution under the selective pressure of the host environment or drug treatment. Long-term infections in immunocompromised hosts are potential drivers of viral evolution and development of infectious variants. We showed that intrahost evolution in chronic human parainfluenza virus 3 (HPIV3) infection...

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Identifiers

PMID: 34609969
DOI: 10.1172/JCI150506
PMCID: PMC8631596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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