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Article

Drivers of adaptive evolution during chronic SARS-CoV-2 infections.

Nature medicine - 1 Jul 2022

Harari Sheri, Tahor Maayan, Rutsinsky Natalie, Meijer Suzy, Miller Danielle, Henig Oryan, Halutz Ora, Levytskyi Katia, Ben-Ami Ronen, Adler Amos, Paran Yael, Stern Adi

Abstract excerpt

In some immunocompromised patients with chronic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, considerable adaptive evolution occurs. Some substitutions found in chronic infections are lineage-defining mutations in variants of concern (VOCs), which has led to the hypothesis that VOCs emerged from chronic infections. In this study, we searched for drivers of VOC-like emergence by...

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Identifiers

PMID: 35725921
DOI: 10.1038/s41591-022-01882-4
PMCID: PMC9307477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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