Prolonged severe acute respiratory syndrome coronavirus 2 infection and intrahost viral evolution in a severely immunocompromised patient with human immunodeficiency virus infection: A whole-genome sequencing study.

doi:10.1016/j.ijid.2026.108453

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Prolonged severe acute respiratory syndrome coronavirus 2 infection and intrahost viral evolution in a severely immunocompromised patient with human immunodeficiency virus infection: A whole-genome sequencing study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2026

Kawashima Akira, Tsuchiya Kiyoto, Kuroki Kenshiro, Nagashima Mami, Koizumi Yoshiki, Nakamoto Takato, Mizushima Daisuke, Aoki Takahiro, Sadamasu Kenji, Teruya Katsuji, Yoshimura Kazuhisa, Gatanaga Hiroyuki

Abstract excerpt

OBJECTIVES: Prolonged severe acute respiratory syndrome coronavirus 2 infection in immunocompromised individuals creates an environment conducive to intrahost viral evolution. We report persistent infection in a patient with advanced human immunodeficiency virus (HIV), aiming to delineate how partial immune reconstitution shapes viral evolution. METHODS: Nasopharyngeal swabs were obtained at 12 time points over a...

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PMID: 41644039
DOI: 10.1016/j.ijid.2026.108453

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