Article
Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease.
Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2018
Pettigrew Melinda M, Ahearn Christian P, Gent Janneane F, Kong Yong, Gallo Mary C, Munro James B, D'Mello Adonis, Sethi Sanjay, Tettelin Hervé, Murphy Timothy F
Abstract excerpt
Nontypeable Haemophilus influenzae (NTHi) exclusively colonize and infect humans and are critical to the pathogenesis of chronic obstructive pulmonary disease (COPD). In vitro and animal models do not accurately capture the complex environments encountered by NTHi during human infection. We conducted whole-genome sequencing of 269 longitudinally collected cleared and persistent NTHi from a 15-y prospective study...
Topics
- Adult
- Amino Acid Sequence
- Evolution, Molecular
- Genome, Viral
- Haemophilus Infections
- Haemophilus influenzae
- Humans
- Mutation
- Phylogeny
- Prospective Studies
- Pulmonary Disease, Chronic Obstructive
- Respiratory System