Article
Within-Host Evolution of Human Influenza Virus.
Trends in microbiology - 1 Sept 2018
Xue Katherine S, Moncla Louise H, Bedford Trevor, Bloom Jesse D
Abstract excerpt
The rapid global evolution of influenza virus begins with mutations that arise de novo in individual infections, but little is known about how evolution occurs within hosts. We review recent progress in understanding how and why influenza viruses evolve within human hosts. Advances in deep sequencing make it possible to measure within-host genetic diversity in both acute and chronic influenza infections. Factors...
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