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Article

Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells.

Journal of virology - 1 Jun 2018

Watanabe Yohei, Arai Yasuha, Kawashita Norihito, Ibrahim Madiha S, Elgendy Emad M, Daidoji Tomo, Kajikawa Junichi, Hiramatsu Hiroaki, Sriwilaijaroen Nongluk, Ono Takao, Takagi Tatsuya, Takahashi Kazuo, Shioda Tatsuo, Matsumoto Kazuhiko, Suzuki Yasuo, Nakaya Takaaki

Abstract excerpt

Transmission of avian influenza (AI) viruses to mammals involves phylogenetic bottlenecks that select small numbers of variants for transmission to new host species. However, little is known about the AI virus quasispecies diversity that produces variants for virus adaptation to humans. Here, we analyzed the hemagglutinin (HA) genetic diversity produced during AI H5N1 single-virus infection of primary human...

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Identifiers

PMID: 29563293
DOI: 10.1128/JVI.02004-17
PMCID: PMC5952156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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