Article
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection.
PLoS pathogens - 1 Jan 2026
Watanabe Yohei, Ibrahim Madiha S, Arai Yasuha, Kuroda Daisuke, Elgendy Emad M, Nakakita Shin-Ichi, Takeda Yohei, Nghia Bui Vuong, Ono Takao, Ushiba Shota, Daidoji Tomo, Sriwilaijaroen Nongluk, Ogawa Haruko, Matsumoto Kazuhiko, Suzuki Yasuo, Nakaya Takaaki
Abstract excerpt
Clade 2.2 H5N1 influenza viruses have caused an unusually high number of human infections, providing a unique opportunity to investigate early molecular steps associated with host adaptation. Although most work has focused on hemagglutinin (HA), the contribution of neuraminidase (NA) to these early adaptive events has remained unclear. By analyzing publicly available sequences from clade 2.2-infected patients, we...
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