Article
A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.
Cell metabolism - 2 Mar 2021
Sinnott-Armstrong Nasa, Sousa Isabel S, Laber Samantha, Rendina-Ruedy Elizabeth, Nitter Dankel Simon E, Ferreira Teresa, Mellgren Gunnar, Karasik David, Rivas Manuel, Pritchard Jonathan, Guntur Anyonya R, Cox Roger D, Lindgren Cecilia M, Hauner Hans, Sallari Richard, Rosen Clifford J, Hsu Yi-Hsiang, Lander Eric S, Kiel Douglas P, Claussnitzer Melina
Abstract excerpt
Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density and glycemic traits and identified a bivariate risk locus at 3q21. Using sequence and epigenetic modeling, we prioritized an adenylate cyclase 5 (ADCY5) intronic causal...
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