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Article

Mechanisms of tau-induced neurodegeneration.

Acta neuropathologica - 1 Jul 2009

Iqbal Khalid, Liu Fei, Gong Cheng-Xin, Alonso Alejandra Del C, Grundke-Iqbal Inge

Abstract excerpt

Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a specific type of slow and progressive neurodegeneration, which involves the abnormal hyperphosphorylation of the microtubule associated protein (MAP) tau. This hallmark, called neurofibrillary degeneration, is seen as neurofibrillary tangles, neuropil threads, and dystrophic neurites and is apparently required for the...

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Identifiers

PMID: 19184068
DOI: 10.1007/s00401-009-0486-3
PMCID: PMC2872491

Genes

MAP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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