Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

Abstract excerpt

Tauopathies are a diverse group of diseases featuring progressive dying back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau. It is well established that the clinical symptoms characteristic of tauopathies correlate with deficits in synaptic function and neuritic connectivity early in the course of disease, but...

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