Article

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

2019-10-31

Abstract excerpt

The microtubule-associated protein Tau is strongly implicated in Alzheimer’s disease (AD) and aggregates into neurofibrillary tangles in AD. Genetic reduction of Tau is protective in several animal models of AD and cell culture models of amyloid-β (Aβ) toxicity, making it an exciting therapeutic target for treating AD. A variety of evidence indicates that Tau’s interactions with Fyn kinase and other SH3 domain–con...

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Literature Corpus work: 491faf00-9060-5ec7-a451-fdfda9479c55
DOI: 10.1101/825760

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