Article

BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair

2023-04-11

Abstract excerpt

<h4>Highlights</h4> Gap suppression requires BRCA2 C-terminal RAD51 binding in mouse and human cells Brca2 heterozygosity in mice results in fork protection and gap suppression defects Gap suppression mitigates sensitivity to hmdU, but only when HDR is unperturbed HDR deficiency is the primary driver of chemotherapeutic sensitivity <h4>eTOC blurb</h4> Lim et al . report that gap suppression as well as fork pro...

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Literature Corpus work: 766dc02f-7d69-557e-a01b-93207518e08f
DOI: 10.1101/2023.04.11.536470

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