Article
Sirt3, Mitochondrial ROS, Ageing, and Carcinogenesis
23 Sept 2011
Abstract excerpt
One fundamental observation in cancer etiology is that the rate of malignancies in any mammalian population increases exponentially as a function of age, suggesting a mechanistic link between the cellular processes governing longevity and carcinogenesis. In addition, it is well established that aberrations in mitochondrial metabolism, as measured by increased reactive oxygen species (ROS), are observed in both...
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